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Some possible triggers can sometimes include: Using two separate drugs to shed pounds can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight-loss and the people that go through it one should err to the side of caution and allow the FDA do its job and demand some research be done so your public knows the side effects and hazards of the medications before we take them. Keep in mind that drug companies are in business to generate income and that they would say everything to keep people on their medications. Researchers discovered that participants investing in this drug for any year, lost weight within one month and have kept the body weight off during the entire 56 weeks with the study. Contrave is often a combination from the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs that are made up of several active ingredient, which can make them more effective and safer. Combo-pilling could be the newest fad or also the newest into the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular could be the fact that since right now there aren't any long term prescription diet pills that have been licensed by the FDA besides orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures really are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug may also raise blood pressure level and heartbeat, and really should not be used in those with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure and heartrate and must stop used in patients with uncontrolled high hypertension, in addition to by a person with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients using a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients on the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking. Other people who should avoid using Contrave are patients struggling with bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave really should not be prescribed for ladies who are pregnant or wanting to become pregnant.